The M6 is currently closed southbound near Knutsford after a collision involving HGVs and a car transporter.
Emergency services are in attendance at the scene and all drivers have been assessed by ambulance staff.
Two drivers have been checked and only suffered minor injuries.
A full closure is currently in place on the southbound carriageway between Junction 19 for Knutsford and Junction 18 for Middlewich.
Delays are expected to build rapidly.
Highways North West have arranged recovery of the vehicles.
After the recovery arrive, North West Motorway Police hope to open lane three.
A spokesman for Cheshire Police said: "Motorist are advised to avoid the area at the current time."
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